Normal Anatomy The breast or mammary gland is covered by skin and subcutaneous tissue and rests on the pectoralis muscle , from which it is separated by a fascial layer . The morphofunctional unit of the breast is a complex branching structure that is topographically arranged into lobes and which is made up of two major components: terminal duct–lobular unit ( TDLU ) and the large duct system . The TDLU is formed by the lobule , made up of acini , and the terminal ductule and represents the secretory portion of the gland. The TDLU is recognized by its distinctly lobular architecture , the presence of a mantle ( intralobular stroma ) of specialized, myxoid-appearing hormone responsive connective tissue, and the absence of elastic fibers . ETD, Extralobular terminal duct; ITD, intralobular terminal duct large duct system . It connects with the subsegmen...
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